Aluminium is present in some manufactured medicines and foods. It is known that aluminium causes oxidative stress. Therefore, the present study was undertaken to determine the effectiveness of Haloxylon salicornicum extract in modulating aluminium chloride (AlCl 3) induced oxidative stress in rats. Male rats (40 to 50 g) were divided into four groups of six animals each. The experimental protocol was based on the administration of AlCl 3 (30 mg/kg/body weight) intraperitoneally (ip) every 5 days for 15 days. The groups treated with the plant receive daily dose of 0.05 g/kg/body weight. Increased level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), urea, and creatinine in serum indicated hepatic and renal dysfunction. The variation of catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), and lipid peroxidation (thiobarbituric acid reactive substances, TBARS) were assessed. These parameters indicated the extent of oxidative damage in liver and kidney, thus confirming the histology results in liver and kidney. It was found that the consumption of H. salicornicum extract protects the liver and kidney against aluminium chloride toxicity. The aim of the present study was to evaluate the protective effect of the H. salicornicum extract on the damages caused by administration of aluminium chloride (AlCl 3) in young rats.

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De par son incidence, le cancer du sein reste le cancer le plus fréquent chez la femme. Cette incidence est faible avant 35 ans et augmente avec l'âge. Il s'agit d'une pathologie mammaire hétérogène avec des variations interindividuelles. Notre étude a porté sur une analyse histopathologique de 81 cas de tumeurs mammaires malignes colligées au niveau du laboratoire d'anatomie pathologique du Pr Bourouis (Oran, Algérie). L'objectif de cette étude est de déterminer les fréquences de chaque type tumoral et d'analyser son aspect histologique et pronostique. Les résultats obtenus ont révélé deux cas de sarcomes et 79 cas de carcinomes. Le type histologique le plus fréquent est le carcinome canalaire infiltrant avec un pourcentage de 76,54 % des cas. Selon la classification histopronostique Scarff-Bloom-Richardson (SBR), 70 % des cas appartiennent au grade III. L'examen des curages ganglionnaires indique que 80 % de ces derniers sont envahis par le processus tumoral.Abstract Through its impact, breast cancer remains the most frequent in woman. This incidence is low before 35 years and increases with age. It is a heterogeneous mammary disease with variations between individuals. Our study has focused on a histopathological analysis of 81 cases of malignant mammary tumors collected in the Laboratory of anatomy pathological (Pr Bourouis Oran, Algeria). The objective of this study is to determine the frequency of each type of tumor and its histological analysis and prognosis. The results obtained revealed two cases of sarcomas and 79 cases of carcinomas. The current histological type is the infiltrating ductal carcinoma with a percentage of 76.54% of cases. According to the histopronostical classification ScarffBloom-Richardson (SBR), 70% of the cases belonged to grade III. An examination of lymph node indicates that the tumoral process invaded 80% of them.

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Le proto-oncogène HER2 code pour une glycoprotéine transmembranaire possédant une activité tyrosinekinase qui conduit à une activation de la transcription nucléaire de gènes régulant la progression du cycle cellulaire. Dans le cancer du sein, la protéine HER2 est surexprimée dans 18 à 20 % des cas. Une étude immunohistochimique est réalisée sur 50 prélèvements de tumeurs du sein, colligées dans la wilaya d'Oran (ouest algérien) dans le but d'évaluer l'expression de la protéine HER2. Les résultats de l'analyse immunohistochimique montrent que 30 % des cas de cancers du sein présentent un statut HER2 positif et 70 % des cas un statut HER2 négatif. Les résultats obtenus montrent que l'étude du profil de l'expression de la protéine HER2 chez les femmes atteintes d'un cancer du sein semble très importante dans la prédiction, le pronostic et la prise en charge. Mots clés Protéine HER2 · Immunohistochimie · Cancer du sein · PronosticAbstract The HER2 proto-oncogene encodes a transmembrane glycoprotein with tyrosine-kinase activity which leads to activation of the nuclear transcription of genes regulating cell cycle progression. In breast cancer, the HER2 protein is overexpressed in 18 to 20% of cases. An immunohistochemical study was performed on 50 samples of breast tumours, collected in the Wilaya of Oran (western Algeria) to evaluate expression of the HER2 protein. The results of the immunohistochemical analysis showed that 30% of cases of breast cancer have HER2 positive status and 70% have HER2 negative status. The results obtained show that the study of HER2 protein expression in breast cancer in women appears to be very important in prediction and prognosis.