We report a copper metallaphotocatalytic 1,2-difunctionalization of terminal alkynes with N-hydroxyphthalimide (NHP) esters and readily available silyl reagents (TMSCN and TMSNCS) to access stereodefined trisubstituted alkenes, including (E)-alkenyl nitriles and thiocyanates. The reaction proceeds with excellent anti-stereoselectivity and demonstrates broad compatibility with a wide range of terminal alkynes and NHP esters as alkyl radical precursors. Experimental and computational studies have been performed to gain insight into the reaction mechanism.

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eview question / Objective To determine the effectiveness of mind-body exercises in improving cognition, memory, executive function and depression in older adults with mild cognitiveimpairment.Condition being studied Mild cognitive impairment (mild cognitive impairment, MCI) is the transition status between normal cognitive changes and dementia (or Alzheimer's disease) during aging, and the prevalence of MCI in the elderly (60 years) in China is as high as 14.0%~15.5% .The 2-year follow-up cumulative incidence of dementia in MCI patients over 65 years was 14.9% ; in another 3-year multicenter randomized clinical trial, 16% of forgotten MCI (amnestic MCI, aMCI) patients developed Alzheimer's disease . However, only 14%~40% of MCI patients remain stable state or return to normal , therefore, exploring effective interventions for MCI is crucial to delay the occurrence and development of dementia . Exercise therapy can improve cognitive function in patients with MCI with good easy availability and economical. METHODSParticipant or population Patients with MCI were included in the study by referring to the diagnostic criteria of Petersen et al. [11] or Expert Recommendations on the Diagnosis and Treatment Process of Cognitive Impairment in the Elderly People.