Aim: Extremity fractures are common in orthopedic trauma. Internal fixation with plate screw, which is among the types of osteosynthesis, is frequently preferred because it provides sufficient stabilization and fixation between bone fragments and is easy to apply. In our study, we aimed to analyze the conditions that may occur during the placement and removal of the plate-screw system for any reason with solidworks-based analysis programs and to offer solutions. Material and Method: When it is necessary to remove the screw, more torque is needed than when it is tightened, and as a result, screw deformations and stripping are encountered. For this reason, it would be more appropriate to use a torque screwdriver during screw placement. We investigated the plate-screw relationship in the locked and unlocked plate screw system with Solidworks 2020 finite element analysis method. Discussion and Conclusion: Our analysis revealed that the most important factor in the platescrew relationship, which is as important as the surgical approach and anatomical reduction, is compliance with the AO principles. It has been observed that if the screw is placed at the appropriate torque and place, the removal of the screw is also done at the same torque during primary surgery.