This paper presented the main information, security problems and threats in open multi-agent distributed e-learning information systems and Proposed various approaches to solve information security attacks in virtual learning environment using service oriented architecture which based on multi-agent information systems architecture, the solution on the multi-agent learning information system implementation based on the implementation of two types of systems the first system with the centralized mobile agent information security management and the second system with decentralized mobile agents security management, and proposed the migration behaviour simulation for their active software components (software agents).