T oday, nanotechnology has a variety of application areas. Pharmacy is one of the most important application fields of nanotechnology. Preparation of nanoparticular drug delivery systems such as nanocrystals could improve the solubility and bioavailability of poorly water soluble drugs. Gemfibrozil (GEM) is a low water soluble drug biopharmaceutical classification system II and used as a lipid regulating agent. In this study, a rapid and simple wet milling method was used for preparation of GEM nanosuspension (GEM NS). The use of sonication after wet milling process reduced the milling time significantly. Different concentrations of stabilizers (polyvinyl pyrrolidone K30 [PVP K30] and Tween 80) were tested for preparation of GEM NSs. The finest GEM NS was obtained by 0.5% w/v GEM, 1% w/v PVP K30 and 2% w/v Tween 80. The size and zeta potential of finest GEM NS were 238.2 ± 2.5 nm and -19.6 ± 0.1 mV, respectively. The morphology of dried GEM NS was observed using atomic force microscopy. Differential scanning calorimetry of GEM and GEM NS confirmed that there was no interaction between GEM and stabilizers. Compared with GEM, the solubility of GEM NS increased significantly.

Experimental molar solubility of clonazepam and diazepam in binary and ternary mixtures of polyethylene glycol 200 (PEG 200), propylene glycol (PG), and water (116 data points) along with the density of saturated solutions at 298.2 K were reported. Also, the experimental solubilities of clonazepam and diazepam in the monosolvents of PEG 200, PG, N-methyl pyrrolidone (NMP), ethanol (EtOH), and water at five different temperatures, (298.2, 303.2, 308.2, 313.2, and 318.2) K (50 data points), have been reported. The Jouyban−Acree model was used to fit to the measurements for providing a computational method. Employing the solubilities in the neat solvents, the measured solubilities were backcalculated, and the overall mean percentage deviations (OMPDs) of the model were 21.4 % and 19.5 % for clonazepam and diazepam, respectively. An addition of the Hansen solubility parameters to the model helps us to train all of the data sets (clonazepam and diazepam) at once, and the back-calculated OMPD was 20.7 %.

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Experimental molar solubilities of clonazepam and diazepam in binary and ternary mixtures of polyethylene glycols (PEGs) 400 or 600, propylene glycol (PG) and water (138 data points) along with the density of the saturated solutions at 298.2K were reported. The Jouyban-Acree model was used to fit to the measurements for providing a computational method. Employing the solubilities in the mono-solvents, the measured solubilities in mixed solvents were back-calculated and the overall mean percentage deviations (OMPDs) of the model were 16.0 % and 19.2% for diazepam and clonazepam, respectively. Addition of the Hansen solubility parameters to the model helps us to train all the data sets (clonazepam and diazepam) at once and the back-calculated OMPD for this analysis was 19.3%.