PurposeIn this manuscript, the authors aimed to demonstrate the influences of influential parameters in mixed-mode crack propagation phenomenon. The authors attempted to cover almost all surrounding issues of this subject as the authors know simulating of propagating cracks as internal strong discontinuity is a complicated issue.Design/methodology/approachIn this manuscript, the authors demonstrated the influences of influential parameters in mixed-mode crack propagation phenomenon. The authors attempted to cover almost all surrounding issues of this subject as the authors know simulating of propagating cracks as internal strong discontinuity is a complicated issue. Furthermore, three different scenarios for crack growth are considered. In reality, edge-cracked plate, center-cracked plate and cracked plate in the presence of void and inclusion are studied. In fact, by designing suitable artificial neural network's (ANN) architectures all the three aforementioned conditions are trained and estimated through those architectures with very good agreement with input data. Also by conducting a series of sensitivity analysis, the most affecting factors in mixed-mode crack propagation in different situations are demonstrated. The obtained results are very interesting and useful for other researchers and also the authors hope the results would be cited by researchers.FindingsThe influential parameters on mixed-mode crack propagation were found in this paper.Originality/valueThe computer code using MATLAB was prepared to study the mixed-mode crack paths. Also using ANNs toolbox, the crack path estimation was investigated.