Background: Non-adherence to treatment regimens can bring about negative effects on the quality of life of hemodialysis patients. Objectives: The present study was conducted to explore the relationship between compliance with treatment regimens and the quality of life in these patients. Methods: This descriptive-analytic study investigated 68 hemodialysis patients who had referred to Imam Khomeini Hospital of Zabol, Southeast of Iran. The subjects were chosen via convenience sampling. Data were collected using a demographic questionnaire, a self-constructed scale for treatment regimen compliance, and the kidney disease quality of life short form (KDQOL-SF). Descriptive statistics, Pearson correlation coefficient, and t-test were used to analyze the data by SPSS 22. Results: The results showed that 77% of patients moderately adhered to treatment regimens, and the mean quality of life in hemodialysis patients was 56.36 ± 17.41. Pearson correlation coefficient revealed a positive significant relationship between the quality of life and compliance with treatment regimens in the study population (P = 0.02). Conclusions: According to the findings of this study, it is recommended that appropriate educational programs should be designed to improve the quality of life in hemodialysis patients by encouraging their adherence to treatment regimens.

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