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Background It is obvious that hemodialysis is a stressful process, leading to numerous social and psychological problems, and may cause fatigue and helplessness. Objective This study aimed to explain the experiences of hemodialysis clients regarding the effect of psychological problems on fatigue. Methods This article was extracted from a qualitative study conducted on clients undergoing hemodialysis in Khorramabad. To this end, a total of 15 participants were purposefully selected using the snowball sampling method and the required data was collected using individual, face to face, detailed and semi-structured interviews. There were 12 client interviewees and one doctor, one nurse and one hemodialysis client's spouse. Content analysis was used to analyze the data. Results Continuous analysis of data and documents obtained from the interviews on the hemodialysis clients' experiences and comments regarding the main causes of fatigue revealed two main categories: 1) Psychological effects with subcategories of psychological stress and exhaustion; 2) Needs and constraints with subcategories of individual and social needs and constraints. Conclusion According to the clients' speech and expression analysis, psychological impacts and disease-induced needs and constraints were the most important cause of fatigue and its continuation among these clients.

Fatigue is one of the main and serious problems that affects haemodialysis patients' quality of life. It should be actively evaluated and, in this process, cooperation between the patient, their family, and healthcare staff is needed to examine fatigue and improve the quality of healthcare and the patient's life. The aim of the present research was to investigate haemodialysis patients' experiences of fatigue. In this qualitative phenomenological study, 12 participants were selected from haemodialysis patients in two health centres in Iran through purposeful sampling. Data were collected through semi-structured in-depth interviews and the collected data were analysed using Colaizzi's method. Two main themes, the nature of fatigue and the perception of fatigue, were found. In addition, the results revealed six secondary themes: physical problems, psychosocial problems, behavioural problems, limitations, need for support, and burnout. The results help to clarify the concept and nature of fatigue for this group of haemodialysis patients.