IntroductionPregnancy and puerperium are universal events that face the majority of women in the reproductive age all around the world, during which major biological, hormonal, and psychological events occur. This study was conducted to verify the hypothesis and investigate (i) psychiatric morbidity in the perinatal period and its comparison with controls. (ii) Is there difference in the psychiatric state across the four perinatal periods? Patients and methods Accordingly, a study was conducted on 105 women who were pregnant or in the postpartum period. They were selected from the outpatient clinic of Obstetrics and Gynecology Hospital in the Ain Shams University. Control nonpregnant women were also selected. They were subjected to Mini International Neuropsychiatric InterviewPlus, Beck Depression Inventory, State-Trait Anxiety Inventory, and Edinburgh Postnatal Depression Scale. ResultsOur study revealed that the prevalence of psychiatric disorders during the first and second trimesters of pregnancy was not significantly different in comparison with controls. However, it is much higher than controls during the third trimester with slight decrease in the postpartum period. The most common diagnosis that was found is adjustment disorder all through pregnancy. There were no significant differences between psychiatric morbidity across the perinatal period. ConclusionWe can conclude that women are vulnerable to psychiatric morbidity in the perinatal period especially in the third trimester and they have high depressive and anxiety states.