Objective: The aim of this study is to compare the outcomes of amoxicillin and cephedrine in oral and dental infections. Study Design: Observational/ Comparative study Place and Duration: Riphah International University, Almizan Campus, Rawalpindi/ Nayab Dental Clinic Rawalpindi. January 2021 to Aug 2021. Methods: Total one hundred and fifty patients of both genders were presented in this study. Demographically detailed of included patients age, sex, cause of infection, residency and education status were calculated after taking informed written consent. Patients had oral and dental infection and did not receive any treatment yet were included. Patients were equally categorized into two groups. Group A had 75 patients and received 500mg amoxicillin while group B had 75 patients treated with 500mg cephredine thrice a day for 5 days. Post-treatment effectiveness among both groups was assessed and compared. SPSS 22.0 version was used to analyze the complete data. Results: There were 40 (53.3%) males and 35 (46.7%) females in group A while in group B 38 (50.7%) males and 37 (49.3%) females. Mean age in group A was 34.13±12.42 years and in group B mean age was 35.04±11.31 years. 100 (66.7%) cases were from urban area (50 in each group). 88 (58.7%) patients were literate (44 in each group). Gingivitis was found in 33 (44%) cases in group A and 35 (46.7%) in group B while frequency of periodontitis was 37 (56%) in group A and 40 (53.2%) in group B. Smoking was the most common cause of infection followed by compromised oral hygiene and diabetes. Post treatment frequency of effectiveness in group B was higher among 63 (84%) cases as compared to group A. Frequency of adverse outcomes stomach upset, diarrhea and dizziness were lower in group B. Change of dose frequently noted in group A among 15 (20%) cases as compared to group B 8 (10.7%). Conclusion: We concluded in this study that use of antibiotics in cure of dental and oral infections were effective and useful but amoxicillin was significantly superior to cephredine with less number of adverse outcomes and higher frequency of germs controlled. Keywords: Dental Infection, Amoxicillin, Cephredine, Gingivitis, Periodontitis