Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant genetic disease. The diagnosis is clinical and is based on two criteria: congenital bone deformities of the hands and feet (in particular a bilateral hallux valgus with a monophalangeal appearance) and ossification of the interstitial connective tissue of the striated muscles (spontaneous or triggered by minimal trauma). This irreversible ectopic osteogenesis evolves in bouts, progressing according to a precise anatomical pattern. The hypothesis of a genetic mutation in the BMP4 signaling pathway, responsible for a dysfunction of the immune system, has been evoked for some years. Recently, a gene involved was identified on chromosome 2: it is ACVR1, one of the BMP receptors. FOP is an example of the difficulty of management, since no curative treatment is effective on the progression of the disease; only preventive and conservative management associated with symptomatic treatment of relapses can be proposed at present.

The acuminate condyloma or rooster crest is a benign sexually transmitted infection caused by human papilloma virus. It is common among sexually active adults and adolescents. His discovery in children raises two problems: identifying the mode of transmission so as not to miss a possible sexual abuse and opt for an appropriate therapeutic choice. We report a case of genital condyloma for a 2,5 old girl with no known risk factors for immunosuppression. We discuss the main epidemiological, diagnostic, therapeutic and evolutionary aspects of this condition in children.

A 9-year-old girl, admitted for hemoptysis with chronic cough and weight loss in a febrile context. The pulmonary Xray showed opacity of the right middle lobe and the thoracic CT showed mediastinal adenopathy necrosé center with focal areas of banded atelectasia. In front of this subacute evolution and the radiological images, tuberculosis was evoked and anti bacillary treatment was started however the phtysiological balance remained negative. After a month of well-conducted treatment, the course was marked by apyréxie and a slight weight gain, but at 3 months, the patient returns for a persistent cough and the appearance of exertion dyspnée. The radio objectivated the persistence of the radiological image and a 2 th thoracic CT an excavated lung disease with medial adenopathy tissue necrotic center. An assessment was requested including negative returned aspergillar serology and bronchoscopy with alveolar broncho lavage with parasitological and bacteriological study. This was in favour of actinomycosis. The child is put on Peni G for 15 days intravenously relaiyée orally by simple amoxicillin for 6 months. Clinical improvement and normalization of chest X-ray is seen with 18-month recoil