Depression is a prevalent psychiatric disorder that often leads to poor quality of life and impaired functioning. Treatment during the acute phase of a major depressive episode aims to help the patient reach a remission state and eventually return to their baseline level of functioning. Pharmacotherapy, especially selective serotonin reuptake inhibitors antidepressants, remains the most frequent option for treating depression during the acute phase, while other promising pharmacological options are still competing for the attention of practitioners. Depression-focused psychotherapy is the second most common option for helping patients overcome the acute phase, maintain remission, and prevent relapses. Electroconvulsive therapy is the most effective somatic therapy for depression in some specific situations; meanwhile, other methods have limits, and their specific indications are still being studied. Combining medications, psychotherapy, and somatic therapies remains the most effective way to manage resistant forms of depression.

Des anomalies fonctionnelles de la thyroïde sont fréquentes et touchent près de 5 % de la population générale, avec une prédominance pour les femmes. La survenue de troubles mentaux, en particulier de l'humeur, au cours des affections thyroïdiennes est connue depuis plus d'un siècle, alors que les troubles psychotiques associés aux dysthyroïdies sont rarement décrits. Nous rapportons les observations de 2 patientes présentant des troubles psychotiques dans deux situations différentes, la première suite à une hyperthyroïdie avec mauvaise observance thérapeutique et la deuxième secondaire à une hypothyroïdie après une thyroïdectomie. Ces observations suggèrent la responsabilité de l'équilibre hormonal thyroïdien dans l'installation des manifestations psychotiques et elles soulignent la nécessité d'éliminer une dysthyroïdie avant tout traitement psychotrope.

People with bipolar disorder are at high risk of serious complications during the COVID-19 pandemic. Limited access to care, lifestyle, health condition and other clinical characteristics increase the risk of contracting the new coronavirus disease, with more risk of developing severe forms, as well as that of bipolar relapse. Here, we will describe some problematic situations that may be encountered by bipolar patients during this pandemic period, and the measures that can be taken to reduce the impact of such problems on bipolar disorder course. Maintaining a daily schedule with relaxing and pleasing activities, getting enough sleep, keeping contact with mental health professionals and continuing prescribed medication, are important measures to prevent relapse. Family and friends, have also a key role in accompanying and supporting patients in these crisis time.