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method is presented for the synthesis of cefpodoxime proxetil (XII), a third-generation cephalosporin for oral administration. Compared to previously reported methods the new procedure affords better yields and no purification step by column chromatography is necessary. -(RODRIGUEZ, J. C.; HERNANDEZ, R.; GONZALEZ, M.; RODRIGUEZ, Z.; TOLON, B.; VELEZ, H.; VALDES, B.; LOPEZ, M. A.; FINI*, A.; Farmaco 58 (2003) 5, 363-369; Ist. Sci. Chim., Univ. Bologna, I-40127 Bologna, Italy; Eng.) -M. Bohle 36-177

(13)C NMR spectroscopic data for 25 cephalosporin derivatives were assigned by combination of one- and two-dimensional experiments. The effect of the substitution at C-3, C-7 and C-4 acid group positions on the chemical shifts of the cephem nucleus is discussed.