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Background : Down's syndrome (DS) is the most common chromosomal abnormality. Some autoimmune diseases are over represented in children with DS like insulin dependent diabetes mellitus, autoimmune thyroiditis and celiac disease (CD). Classical presentations of CD may be absent in children with Down's syndrome. Worldwide different tests are available for the diagnosis of CD. Among these, tissue transglutaminase (tTG) is cost effective, sensitive and the only test available in Bangladesh.

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