BackgroundA 57-year old woman had only unilateral milky dischardge of the right breast. Clinical and mammography findings were normal.Case presentationCytological diagnosis of intraductal papilloma was established which was galactographically confitmed and patient underwent to surgery. Ductulolobular segmentectomy was made. Histopathologically beside intraductal papilloma numerous single dispread malignant "signet ring" cells in the fibrous retromammilary stroma were found. Imunohistochemically findings were: cytokeratin 8 positive, ER H-score 80, PR H-score 50, HER-2/neu negative. Diagnosis of "signet ring" cell lobular invasive carcinoma was made, followed by mastectomy, axillary limphadectomy and contra lateral breast biopsy.ConclusionResidual tumor were found only in the breast tissue, while axillary lymph nodes and contra lateral breast biopsy were negative. Patient underwent to oncology therapy.

Objectives: The purpose of the study was to determine the difference in time until the appearance of relapse or metastases in patients treated for colorectal cancer, depending on the location of the tumor in the left or right colon at the oncology clinic of clinical Medical centre osijek between 1 st January 2010 and 31 st December 2012. Study design: historical prospective studyMaterial and methods: study included patients whose data were recorded from medical archive at the oncology clinic of Clinical Medical Centre Osijek. The data on patients' deaths were recorded from the Registry Office of the Republic of croatia.Results: the study included 272 patients, 160 (58.8%) men and 112 (41.2%) women. according to the location, left sided colon tumor was discovered in 211 (77.6%) patients and right-sided in 61 (22.4%). the median age was 67 years. right-sided colon tumors are considerably larger with median diameter of 6 cm, with median number of 16. Median of time until the appearance of the metastases is 20 months (interquartile range is from 8 to 29 months); marked time being shorter in right-sided colon tumors. Positive outcome of the treatment was achieved in 205 (75.4%) patients, with no significant difference in comparison to the colon cancer localization. By using Kaplan-Meier analysis of patients' survival rates, a total 5-year survival rate of 72% was achieved in right-sided colon tumor in comparison to 62% in patients with the left-sided colon tumor.Conclusion: This study confirms that there is a difference in colorectal cancer according to its localisation. Patients with right-sided colorectal cancer are older, the carcinoma is larger, the time until the appearance of a relapse or a metastases is shorter in right sided colon cancer while 5-year survival rate is lower in left sided colon cancer. KeYWorDs: colorectal cancer, oncology, colon RAZLIKA IZMEĐU KARAKTERISTIKA BOLESNIKA S KARCINOMOM LIJEVOG I DESNOG KOLONA -ISKUSTVO JEDNE USTANOVE Sažetak Cilj Istraživanja: Utvrditi razliku u vremenu do pojave recidiva ili presadnica kod bolesnika liječenih zbog kolorektalnog karcinoma ovisno o smještaju u lijevom ili desnom kolonu u pacijenata liječenih na Zavodu za onkologiju, KBC-a Osijek od 1. siječnja 2010. do 31. prosinca 2012. lib oncol. 2019;47(2-3):41-47 42 Nacrt studije: povijesno prospektivna studija Materijal i metode: U istraživanje su uključeni ispitanici čiji su podatci preuzeti iz arhive medicinske dokumentacije Zavoda za onkologiju KBC-a Osijek, podatci o smrti pacijenata preuzeti su od nadležnog Maticnog ureda Republike Hrvatske. Rezultati: U istraživanje je uključeno 272 pacijenta, od kojih je 160 (58,8 %) muškaraca i 112 (41,2 %) žena. Prema lokalizaciji, ljevostrani tumor kolona ima 211 (77,6 %) bolesnika, a desnostrani njih 61 (22,4 %). središnja dob pacijenta (medijan) je 67 godina. Značajno su veći u promjeru desni tumori kolona, medijana 6 cm. Medijan vremena do pojave metastaza iznosi 20 mjeseci (interkvartilnog raspona 8 do 29 mjeseci), pri čemu je značajnije kraći kod desnih tumora kol...