A significant feature of Pakistan's agriculture is that it is served by the Indus irrigation system, which is one of the largest contiguous irrigation systems in the world. The system comprises of the Indus River and its tributaries, three major storage reservoirs, 19 barrages/headworks, 43 canals, and 12 link canals and 43 canals covering about 43,000 chaks or village settlements. The total length of the canal system is about 40,000 miles with over 80,000 water courses, field channels ' and ditches running for another million miles. About 100--106 million acre feet (MAP) of surface irrigation supplies are diverted annually into the canal system. Only 60 percent of this water reaches the farmgate due mainly to low efficiency in the delivery of water. The historical review of the area, production and yield trends shows that agricultural production in the past has increased mainly due to expansion in irrigated acreage while the contribution of changes in yields has been insignificant. In general, agricultural production can be increased by either expanding the irrigated cropped area or by raising the crop yields. It is highly unlikely that Pakistan will be able to satisfy the food needs of the rapidly increasing population through yield increases alone. This means that there ia a need to increase the irrigated cropped area through additional water supplies and by improving the efficiency of water use through using the water resources in a scientific manner.
Purpose: To assess the analgesic role of neuroleptics in hyperglycemic state.Methods: Amytryptiline and carbamazepine were selected for study. This study was carried out at Pharmacology lab, Institute of Research Pharmaceutical sciences, University of Karachi, and comprised of male and female mice, half of which were made diabetic by giving Alloxan. The objective of this study is to monitor the effects of neuroactive agents on analgesic activity in hyperglycemic mice. Results:It was observed that Amytryptiline exhibited highly significant analgesic effect in normal as compared to diabetic subjects. It was also observed that both amytryptiline and carbamazepine produce more rapid onset of action and longer duration of action in normal animals when compared with diabetic animals. Conclusion:The present work on normal and diabetic animals show that both Carbamazepine and Amytryptiline in normal animals produce rapid onset and longer duration of action when compared with diabetic animals.
The objective of this study was to assess the demographic profile, severity of patient, co morbidity, length of stay (LOS) and management of community acquired pneumonia. The study was a prospective study and consist of 212 patients (>20 years of age) with community acquired pneumonia (CAP) hospitalized to the tertiary care hospital, situated in Karachi between 1st January, 2010 and 31st March, 2012. Information related to demography and socioeconomic condition (gender, age, education, occupation and household income) and clinical details includes, evaluating severity using pneumonia severity index (PSI) score, laboratory finding, initial antibiotics prescribed, and hospital stay were composed. Demographic, socioeconomic and clinical variables were analyzed using descriptive statistics which is presented as percentage, frequencies, range and means. 116 (54.7%) patients had less severe pneumonia; 60 (28.3%) patients had moderately severe CAP and 36 (16.98%) patients had severe pneumonia. Commonly prescribed monotherapy of antibiotics initially on hospitalization were intravenous ceftriaxone 36 (16.98%). We recommend prospective multicenter setting studies to analyze the prevalence and burden of CAP in Pakistan. Improved assessment and proper utilization of guidelines is mandatory in the management of patients admitted with CAP.
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