ARDS Acute respiratory distress syndrome BSL Biosafety level 3CLpro 3C-like serine protease COVID-19 Coronavirus disease 2019 This article has not been copyedited and formatted. The final version may differ from this version.

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Introduction: 441Discussion: 3727 List of abbreviationsORF, open reading frame; NSP, non-structural protein; 3CLpro, 3-chymotrypsin-like protease; PLpro, papain-like protease; ACE2, angiotensin-converting enzyme 2; TMPRSS2, transmembrane protease serine 2; RdRp, RNA-dependent RNA polymerase; ISG15, interferon-stimulated gene 15 protein; CPE, cytopathic effect; HTS, high throughput screening; FRET, fluorescence resonance energy transfer; AMC, 7-amino-4-methylcoumarin This article has not been copyedited and formatted. The final version may differ from this version.