Introduction: Pharmaceutical drugs-antibiotics are given to livestock by veterinarians for the prevention or/and treatment of disease, but also as a stimulant for animal growth and conversion. Regardless of the way the drugs are inserted into the body of the animal, there will always be residual risk in milk which exceed the maximum level allowed. Thus, given that milk contains high level of drug residue, it can lead to health disorders in humans and in some cases even death. Aim of study: The main aim of this study is to discover the use of pharmaceutical drugs-antibiotics in dairy cows and to detect betalactam and sulfonamide residues in milk. Methods and materials used: In 2011, during the period January to August, 80% of dairy farms in the Republic of Kosovo were visited and 127 milk samples were collected from cows treated with pharmaceutical drugs-antibiotics. Samples were analysed ÿ'3fÿ'3fin the laboratories of the Veterinary Institute in Skopje using "Elissa" screening method and "HPLC" confirmatory method. Results: Of 127 samples of milk, 64 of them were contaminated with betalactam residues, while 24 with sulphonamide residues. Of them, the majority, 15 being beta-lactams and 4 sulphonamides. The study shows that over 70% of the total quantity of milk samples analysed contains residues of drugs, while over 20% of them have passed the maximum residue limit allowed. Conclusion: 70% of the drugs given to dairy cattle in Kosovo are pharmaceutical-antibiotics. Their residues are present in milk at levels high enough to cause severe damage to the entire public health. We conclude that pharmaceutical drugs-antibiotics that are used in humans should not be used in animals too and their provision should be limited to a reasonable and lawful level.