Background: Lipid profile effects is a risk factor for Coronary Heart Disease. Soursop leaves (Annona muricata L) isa traditional medicine plant containing metabolic compounds that contribute to the improvement of the lipid profile.Objective: To determine the effects of soursop leaves extract on lipid profile (total cholesterol, LDL cholesterol, HDLcholesterol and triglyceride).Methods: An experimental study using randomized pre-posttest with control group design. Sample consisted of 28 maleWistar rats, were divided into four groups. The control group (K) was only given High Fat High Cholesterol (HFHC)diet and treatment groups (P1, P2, P3) were given a HFHC diet plus Annona muricata L extract with doses of 100, 200and 300 mg/kgBB per day for 28 days respectively. Data were analyzed by Wilcoxon test, Kruskal-Wallis and MannWhitney.Results: The mean total cholesterol level significantly decreased in the treatment group P1 (p = 0.028) from 60.7 mg/dl(47.6-75.3) to 45.5 mg/dl (38.4-62.4). Mean HDL cholesterol level significantly increased in the treatment group P2(p=0.043) from 26.0 mg/dl (19.7-35.3) to 27.9 mg/dl (18.8-38.0). The mean levels of LDL cholesterol and triglyceridedecreased but not significantly.Conclusion: The administration of Annona muricata L extract can decrease total cholesterol and increase HDLcholesterol significantly.

Tidal inundation is a flood that usually occurs in the coastal region. It will impact water quality, which may lead to health problem. A semi-quantitative tool was use to assess water quality in Bandarharjo Village, a tidal inundation affected area. Total coliform was also performed to aseess bacterial contamination. The assessment was conducted at three sites of drinking water supply system: source/provider, distribution, and customer levels. The result showed that both provider and distribution levels have very high risk of contamination, while customer level has a high risk. Water from either source/provider and customer level contained bacterial contamination.

Background: Health status can affect the Human Development Index (HDI) of a country. To improve the quality of human resources, the Indonesian Government has applied various policies, such as the nutrition improvement program, since there are still lots of toddlers suffering from underweight, wasting dan stunting. Even one out of three toddlers in Indonesia were detected stunting.Objectives: This study described the implementation of a nutrition improvement program for toddlers in the Central Buton District Health Office.Materials and Method: This was a qualitative study that involved ten informants. Three of those informants are nutritionists in the District Health Office, Head of Public Health Department, Head of NutritionDepartement. Also, two nutrition workers in primary healthcare centers and two mothers of malnourished toddlers.Results: These findings showed that in terms of input, trained human resources on nutrition were lacking, and the budget for the nutrition improvement program was inadequate. While, in the process, all implementors had done very well, although they still had no collaboration across sectors. In the output aspect, the health status of underweight, wasting, and stunting toddlers improved. Also, monitoring and evaluation were conducted on toddlers registered at the integrated service posts in 2018.Conclusions: There were still constraints on the input, process, and output aspects, even though there was an increase in the nutritional status of children under five, but nutrition problems for children under five in Central Buton Regency were still high.

One of the main occupations in fish auction facilities was transport worker. Manual handling activities are a leading cause of workplace injuries such as strains and back injuries. This study aims to analyze the association between ergonomic posture with muscle tension, lactic acid buildup, and work performance. This study was carried out in November 2020. The instruments in this study were portable electromyography, lactate analyzer, REBA Assessment sheet, and questionnaire. The analysis was performed with statistical test using Fisher Exact Test. This study is analytical survey research with cross-sectional study design with 51 respondents selected using convenience sampling method. Based on the data obtained, it was found that 36 respondents (70.59%) did not work ergonomically. The result of the analysis is that there is an association between ergonomic posture and muscle tension (p=0.000) and lactic acid buildup (p=0.002), but there is no association between ergonomic posture and work performance (p=0.761). It is necessary to improve the quality of fish auction facilities services by providing ergonomic transportation aids such as lifting trolleys and training related to the dangers of ergonomic risk factors at fish auction facilities.