A new platelet aggregation inhibitor, bassiatin, was isolated from the cultured broth of Beauveria bassiana which had been isolated from a soil sample collected in Yunnanprovince, China. The structure of bassiatin was determined to be (35,6i^)-4-methyl-6-(l-methylethyl)-3-phenylmethyl-l ,4perhydrooxazine-2,5-dione by NMRanalysis, X-ray crystallographic analysis and chemical synthesis. Bassiatin inhibited ADP-induced aggregation of rabbit platelets with the IC50 being 1.9 x 10~4m.

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During our screening program for natural product drugs effective against multidrug-resistant mammalian cells, we have discovered a new S lactone FD-211 from the fermantation broth of Myceliophthora lutea TF-0409. FD-21 1 had a broad spectrum activity against cultured tumor cell lines, including adriamycin-resistant HL-60 cells.

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