Three-dimensional (3D) chemical models are a well-established learning tool used to enhance the understanding of chemical structures by converting two-dimensional paper or screen outputs into realistic three-dimensional objects. While commercial atom model kits are readily available, there is a surprising lack of large molecular and orbital models that could be used in large spaces. As part of a program investigating the utility of 3D printing in teaching, a modular size-adjustable molecular model and orbital kit was developed and produced using 3D printing and was used to enhance the teaching of stereochemistry, isomerism, hybridization, and orbitals.

3D printing has the potential to transform the way in which chemical reactions are carried out due to its low-cost, ease-of-use as a technology and its capacity to expedite the development of iteratively enhanced prototypes. In this present study, we developed a novel, low-cost polypropylene (PP) column reactor that was incorporated into an existing continuousflow reactor for the synthesis of heterocycles. The utility and

In this present study, we describe the development of a low‐cost, small‐footprint and modular 3D printed continuous‐flow system that readily attaches to existing stirrer hotplates. Flow‐rates are controlled by compressed air that is typically present in all fume hoods, making it suitable for use by synthetic chemists. The length of the flow‐path and reaction residence time is regulated by control of the air‐flow and pressure and by addition of one or more 3D printed polypropylene (PP) circular disk reactors that were designed to fit a DrySyn Multi‐E base, which is found in most synthetic laboratories. The ease of use of the system, the facile control of flow‐rates and the solvent resistance of the PP reactors was demonstrated in a range of SNAr reactions to produce substituted ether derivatives highlighting the utility and modularity of the system.

An intramolecular acylal cyclisation (IAC) approach to the synthesis of a range of bicyclic heterocycles is reported. As an example of the utility of the IAC reaction, the methodology was applied in a protecting-group-free five-step total synthesis of (±)-γ-lycorane, incorporating a new intramolecular Heck addition reaction to generate the pentacyclic core structure of the natural product in good yield.

3D printed materials can be readily modified to create bespoke structures that incorporate a range of catalysts at the point of printing. In this present study we report on the...