The aims of this study is to determine the effectiveness of antifungal Soursop leaf extract against the fungus Candida albicans and determine the class of compounds that act as vaginal discharge. Soursop leaf was extracted using maceration method with 96% ethanol solvent then concentrated with a rotary evaporator. The class determination of active compound by using multilevel composition fractionation method with n-hexane, chloroform, and ethyl acetate solvent. The effectiveness test of antifungal of each fraction toward Candida albicans by diffusion method is so that the researcher can look at the inhibitory zone diameter, then identify them by using UV-VIS and FTIR spectrophotometry to determine the active compound as antifungal. The highest antifungal effectiveness of soursop leaf active compounds was the n hexane fraction with inhibition diameter 23.7 mm which was categorized as strong, compared to the positive control of ketoconazole with inhibition zone 22.5 mm and nystatin 15, 9 mm. The compound which is thought to have antifungal activity from the n- hexane fraction of soursop leaves is a terpenoid compound.

The purpose of this study is to determine the effectiveness difference of red betel plus soursop leaves decoction and soursop leaf decoction against leukorrhea in hormonal contraceptive acceptors in the working area of Regional Public Service Agencies of Public Health Center in Tembelang. It is a pre-experimental research design with two groups pretest and post test design. The population is all of the hormonal contraceptive acceptors who had leukorrhea in the Regional Public Service Agencies of Public Health Center in Tembelang. 30 subjects group of cases with vaginal wash treatment using red betel mixed with soursop leaves decoction and 30 subjects control group with vaginal wash treatment using soursop leaf decoction. The samples were taken by using purposive sampling technique which the independent variable was vaginal wash treatment using red betel and soursop leaves decoction, and the dependent variable is Leukorrhea. The research instrument used was the observation sheet and the data were analyzed by using the T test. The T test of the two treatments was statistically significant with P value is 0.001. The decoction of red betel (Piper Croratum) leaf and soursop (Annona Muricata L) leaf is more effective in curing complaints of leukorrhea in women who experience female reproductive organs problems related to leukorrhea.

Background:The negative effect of low hemoglobin levels for adolescents can reduce intelligence, learning achievement, mental motor development, inhibition of optimal height growth and reproductive health. Dysmenorrhea is pain or discomfort that occurs in the abdomen during menstruation as a result of prostaglandin secretion which can increase uterine contractions. The purpose of this study was to determine the effect of Remakuda juice on an increase in hemoglobin and a decrease in the intensity of dysmenorrhea in female adolescents. Subjects and Method: An experimental study with no control group was conducted at Junior High School I Tembelang, Jombang, East Java, in September 2021. A total of 60 female adolescents was selected by purposive sampling. The dependent variables were hemoglobin level and dysmenorrhea. The independent variable was Remakuda juice. Dysmenorrhea was measured by the Numeric Rating Scale (NRS) and the Wong Baker Pain Rating Scale. Hemoglobin level was measured by digital haemometer. The data were analyzed using t-test. Results: Hemoglobin levels after intervention (Mean= 2.00; SD= 0.00) were higher than before (Mean= 1.73; SD= 0.45), with p= 0.010. Dysmenorrhea after intervention was lower (Mean= 1.43; SD= 0.59) than before (Mean= 2.70; SD= 0.65), with p<0.001. Canclusion: Remakuda juice can increase hemoglobin levels and reduce dysmenorrhea in female adolescent.

Newborns are prone to physiologic icterus characterized by yellow mucosa and baby's skin due to deposition of heme catabolism, bilirubin. Various prevention can be done to prevent jaundice of newborns to become hyperblirubinemia. The purpose of this study was to analyze the relationship between the reduction in physiologic jaundice in neonates. Analytic observational research design, samples of all babies born in Mombykids Jombang in November 2019 -March 2020 were 60 babies, purposive sampling technique, instruments used were observational sheets and fisher's exact test was analyzed. Early breastfeeding initiation done for one hour y 75%, sunbhating done for 15-30 in the morning minutes as much as 80%, decreased physiological signs of jaundice as much as 80%, there is a relationship between early breastfeeding initiation, sunbhating with decreased physiological signs of jaundice during neonates with fisher's exact test p = 0,000 α = 0.05. Educating mothers and breastfeeding on the importance of prevention of jaundice during neonates about the benefits of giving early breastfeeding initiation, namely providing the opportunity for newborns to immediately get breast milk in the form of collustrum and do neonatal drying in the morning sun for 15- 30 minutes.

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