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Purpose: To analyze the incidence and risk factors of lower extremity venous thrombosis after urologic surgeries. Methods: A prospective two-center study was conducted from August 2019 to January 2020. 1122 consecutive patients who underwent urologic procedures were enrolled. The study primary end point was the detection of asymptomatic or symptomatic deep vein thrombosis (DVT) of lower extremity within 7 days after the surgeries. Univariate and LASSO-logistics regression analysis were performed.Results: We excluded 111 patients who met exclusion criteria. Totally, 56 (5.54%) out of 1011 patients had developed DVT. In the univariate analysis, Barthel Index ≤40, D-dimer levels ≥0.5mg/L and age≥ 60 yrs (p <0.001) were the most significant risk factors. The LASSO-logistics regression model identified 9 factors including age, history of DVT, lymph nodes dissection, perioperative steroid use, Caprini Score, Barthel Index, D-dimer levels, cystectomy and prostatectomy.Conclusion: Our study used the LASSO-logistic regression model to provide reliable data on risk factors of DVT after comprehensive urologic surgeries. It might facilitate individualized anticoagulant management of patients undergoing urologic procedures.Trial registration: ChiCTR1900024784