Although 3 months of androgen deprivation before radical prostatectomy resulted in an apparently significant decrease in positive surgical margins, a 5-year followup does not indicate any difference in the recurrence rate. Until studies document improvement in biochemical or clinical recurrence with longer periods of treatment, induction androgen deprivation before radical prostatectomy is not indicated.

The Journal of Urology 154 (1995) 424-428. doi:10.1016/S0022-5347(01)67067-8Received by publisher: 0000-01-01Harvest Date: 2016-01-04 12:20:26DOI: 10.1016/S0022-5347(01)67067-8Page Range: 424-42

Valrubicin was effective and well tolerated in patients with carcinoma in situ of the bladder refractory to BCG therapy. Delaying cystectomy while attempting salvage therapy with valrubicin does not pose an undue risk to most patients.