No abstract

The dendrimers are the macromolecules that branch out from the same nuclear and they finally reach the same central nucleus. The solubility of the dendrimer is strongly affected by the surface groups. These compounds are the ideal carriers for biomedical applications. One of the oldest identified dendrimer is poly (propylene imine) dendrimer (denoted as PPI dendrimer). The present study consists of two sections. In the first section, the interaction between the (PPI) dendrimer with different molar ratios of curcumin was investigated at the presence or absence of the ultrasonic waves. In the second section, the anti-cancer effects of this compound on BRC-9 cell line (of breast cancer cells) were investigated with the help of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay.

In this work, the interaction between curcumin and hydrazine was studied in three different conditions: In the presence of ultrasonic waves, in the absence of ultrasonic waves, and while refluxing and the effects of the produced materials on the livability of bone marrow mesenchymal stem cells were investigated. Various methods including FT-IR, 1 H NMR and 13 C NMR were utilized to characterize the material. The results revealed that cell treatments with 40 μM dose of all three samples after 24 h were caused to the more biological ability of rat bone marrow mesenchymal stem cells (MSCs). This indicated that these compounds (curcumin-hydrazine) are effective in the livability of bone marrow mesenchymal stem cells (MSCs).