Everyone knows that test cultures are used to control and quality the growth properties of nutrient media, to check the activity of antiseptics and disinfectants, as well as to assess the adequacy of the sensitivity of the tested microorganisms to new antibacterial drugs, which are currently produced by rapid temp. with the development of antibiotic resistance of microorganisms to most of the active substances used in new drugs. Moreover, it is the understanding that most antibiotics are clinically useless in treating infectious diseases because of their long-term use for chemotherapy purposes – a major problem not only in Ukraine but worldwide. In this article the results of researches sensitivity museum strains, namely: Escherichia coli ATCC 25922 (F-50), Pseudomonas aeruginosa ATCC 2853 (F), Proteus vulgaris HX 19 number 222, Staphylococcus aureus ATCC 25923, Enterobacter aerogenes 10006, Enterococcus faecalis ATCC 19433 to the antibacterial drug “Saroflox”. We find that Saroflox inhibited the growth of all test cultures at different dilution rates. Using different concentrations of the antibiotic (2.5 mg, 1.25 mg, 0.625 mg, 0.3125 mg, 0.1562/200 μl), it was found that all test cultures under study were highly sensitive to Saroflox. most from 38.0 ± 1.0 to 20.0 ± 1.0 mm. The results of studies show that the new antibacterial drug “Saroflox” has bactericidal properties to most cultures that cause bacterial diseases of various species of animals and birds, which only confirms its effectiveness against gram-negative microorganisms (Enterobacter spp. , Staphylococcus aureus E. coli and others) including beta-lactam antibiotic resistant, tetracyclines, macrolides and aminoglycosides.

Сумський державний університет РОЛЬ МОНІТОРИНГУ ТА КОНТРОЛЮ ЗА ТОКСИКОІНФЕКЦІЯМИ ТА ТОКСИКОЗАМИ У ЗАБЕЗПЕЧЕННІ БІОБЕЗПЕКИ НАСЕЛЕННЯ УКРАЇНИ Моніторинг збудників токсикоінфекцій та токсикозів в різних зонах України проводили за період 2015-2017 рр. При проведенні ретроспективного аналізу ізоляції збудників частіше всього токсикоінфекції та токсикози у людини викликались збудниками клебсієльозу (

The use of nanomaterials has become especially relevant as components of new drugs, adjuvants and new ingredients in feed additives. The very combination of inorganic components (metals) with natural minerals (сeolites, clenoptolites) made it possible to create fundamentally new chemical compounds that differ significantly in the mechanism of action and their physicochemical characteristics from traditionally used drugs for the treatment of bacterial diseases of poultry. The practical application of the composition involves the use of small sizes of nanoparticles that are in the “nanoscale” from 1 to 100 nm. Our article contains the results of studies of Ag and Zn nanomaterials in combination with citrate in the form of powder and dispersed solutions. As a result of scanning electron microscopy, it was found that the studied sample of Ag and Zn nanoparticles is a gray powder of monocrystalline particles of irregular shape, the size of which varies from 160 to 350 nm. Particles of three sizes were most often found among Ag and Zn citrates, namely: 160 nm – 45 %, 210 nm – 35 %, 350 nm – 20 %. Studying the bactericidal properties of dispersed solutions of Ag and Zn citrates on microbial suspensions of test cultures of Escherichia coli (ser.O2), Salmonella typhimurium, Pseudomonas aeruginosa, Staphylococcus epidermidis, we found that Ag citrate showed better bactericidal properties in relation to all experimental test cultures of Escherichia coli (ser.O2), Salmonella typhimurium, Pseudomonas aeruginosa, Staphylococcus epidermidis, in contrast to the citrate solution Zn, which was only effective against Escherichia coli (ser.O2), and Staphylococcus epidermidis.