Aim of research: To determine the frequency and degree of decrease in bone mineral density in women of reproductive age who are descendants of persons exposed to radiation as a result of nuclear tests at the Semipalatinsk test site. The study included 383 women, descendants of non-irradiated and irradiated II and III generations in the female line. The parameters of bone mineral density in 2 age groups (II generation - 1962-1987 year of birth and III generation – 1988-1996 year of birth) were studied by ultrasound densitometry. It was revealed that women of reproductive age with irradiated ancestors of the second and third generation, who lived in areas of maximum and extreme radiation risk, had a relative decrease in bone mineral density, which was statistically significant in relation to the descendants of persons who were not exposed to chronic anthropogenic sources of ionizing radiation. There were statistically significant relationship between exposure ancestors II and III generation and indicators BMD their offspring, women of reproductive age. It is possible to predict the rapid development of involutional osteoporosis in women-descendants of irradiated patients in the ІІ and ІІІ generation.