The bell tower of Nanking University, built in 1888, is a milestone of modern educational architecture in Nanjing. It fully introduced Western architectural concepts and is an important historical witness to the cultural exchange between China and the West. At present, there are few studies on the conservation and reuse of the building, so the authors conducted the project. In this paper, we conducted research by combining qualitative and quantitative methods. The qualitative analysis includes analyses of historical maps, photos, text, surveys, mapping of buildings, and a comparative analysis. The quantitative analysis includes statistics on the distribution of the urban school architectural heritage, the number of buildings at Nanking University, and China’s school building design standards. Through the historical research and value analysis of the building, we explore its real information from the aspects of architectural style, space, structure, material, and construction technology, and propose a reasonable conservation method. According to the current urban planning policy and architectural heritage data, the functional upgrading and renovation of the building will be carried out. This paper explores authenticity and integrity-based restoration methods, as well as the adaptive-reuse strategy for China’s architectural heritage, which can provide a paradigm for regional development and historic campus renewal.