Axillary hyperhidrosis (AH) and bromhidrosis are common complaints in Asians for consultation in dermatology. A microwave-based device has gradually become a first option option during this decade because of the safety and efficacy both for AH and osmidrosis. Other complications reported are transient median and ulnar neuropathy and brachial plexus injury with sensory and motor dysfunction. We herein report a rare case of subcutaneous tissue necrosis with fat liquefaction, hematoma that occurred after microwave-based treatment. It took 3 weeks for both sides to recover completely. The case prompt us that one pass treatment for the same treatment area and cooling to relieve the pain for 24 h. Appropriate restriction of movement should be emphasized within 1 month after treatment. Moreover, caution is needed when bumps enlarged rapidly. How to cite this article: Zhang B, Huang L. Subcutaneous tissue necrosis with fat liquefaction, hematoma, inflammatory mass after microwave-based treatment for axillary hyperhidrosis.

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