Abstract. Target-centric warfare is a new warfare mode and means with various intelligent entities that form an adaptive loop. Based on analysis on the process of target-centric warfare, agent and multi-agent system technology is used and agent-based target-centric warfare models including interaction protocol model and behavior simulation model are designed. Thus, agent-based target-centric warfare simulation is implemented. The feasibility and efficiency of the proposed approach is validated by case study of Red-Blue Forces counterwork.