The sequence diagram can be used to design object-oriented software; however, its modeling principles are lack of research. In this paper, its application in software design was studied, and its inherent linkage with object-oriented programming was discussed, and the interactive mechanism among its elements was explored. The modeling principles for it were proposed; and its application in Model Driven Architecture (MDA) software paradigm was analyzed; and finally the model represented with it, especially the transformation and traceability of models in MDA software paradigm were analyzed. This research is useful to optimize software modeling and to automate model transformation in MDA software paradigm.
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