These beneficial effects make rhNRG-1 promising as a broad-spectrum therapeutic for the treatment of heart failure due to a variety of common cardiac diseases.

Natural killer/T-cell lymphoma (NKTCL) is a rare subtype of non-Hodgkin lymphoma that is associated with a poor outcome. Currently, the treatment needs of NKTCL remain unmet, and efforts to further improve treatment are urgently needed. Herein, seven patients with NKTCL who failed to respond to various types of chemotherapies were treated with the anti-programmed death 1 (anti-PD-1) antibody pembrolizumab at 100 mg every 3 weeks. After a median of four cycles of treatment (range 2–18), four out of seven patients responded (two complete response, two partial response, overall response rate 57%). Expression of PD1-ligand available was 50, 20, 30, 70, and 30% of five patients respectively. It is negative in one patient and not tested in one patient. Adverse events, which mostly ranged from grade I to grade III, were tolerable and could be safely handled, although immune-related pneumonitis was notable. Overall, PD-1 blockade with pembrolizumab represents a favorable strategy for the treatment of refractory/relapsed NKTCL.

We report the polarized optical absorption spectra of single-walled 4 Å carbon nanotubes arrayed in the channels of an AlPO 4 -5 single crystal. When the light electric field ͑E͒ is polarized parallel to the tube direction ͑c͒, the spectra display a sharp peak at 1.37 eV, with two broadbands at 2.1 and 3.1 eV. In the EЌc configuration, the tube is nearly transparent in the measured energy region 0.5-4.1 eV. The optical dipole selection rules are discussed, and the absorption bands are assigned to the dipole transitions between the Van Hove singularities. The measured absorption spectra agreed well with the ab initio calculations of band structure based on the local density function approximation. DOI: 10.1103/PhysRevLett.87.127401 PACS numbers: 78.67.Ch, 61.46. +w, 73.22.-f, 82.75.Mj In 1993, Iijima's group as well as Bethune's group found that the use of transition-metal catalysts leads to nanotubes with only a single wall [1]. A single-walled carbon nanotube (SWNT) is wrapped from a two-dimensional graphite sheet. The diameter of each freestanding SWNT ranges from 0.7 to a few tens of nanometers with a maximum length of about 1 mm. Within the band-folding scheme, the diameter and the chirality of a SWNT are believed to determine whether the nanotube is metallic or semiconducting [2]. Their electronic densities of states have Van Hove singularities, which have been directly observed by scanning tunneling spectroscopy [3]. Optical absorption spectra have been measured for bundles of SWNTs and nanotube thin films [4]. The absorption bands can be attributed to optical transitions between the Van Hove singularities. More controlled experimental studies on the optical properties for SWNTs are, however, not easy to carry out because of the technical difficulty in fabricating monosized and well-aligned nanotubes. Recently, SWNTs with a diameter as small as 4 Å have been produced in the 1 nm-sized channels of the AlPO 4 -5 single crystals (AFI in the zeolite terminology) [5,6]. Very recently, one-dimensional superconducting fluctuation with a mean-field superconducting temperature of 15 K has been observed in the 4 Å SWNTs [7]. A 4 Å nanotube has also been synthesized by the mass-selected carbon ion beam deposition as the inner shell of an eighteen-layered multiwalled nanotube [8]. The system of the monosized SWNTs stabilized in the zeolite channels brings the experimental results much closer to the reality of theoretical predictability.In this Letter, we report polarized absorption spectra for the 4 Å SWNTs arrayed in the one-dimensional channels of an AFI single crystal. AFI is a type of porous aluminophosphate single crystal. Its framework consists of alternate tetrahedra of ͑AlO 4 ͒ 2 and ͑PO 4 ͒ 1 which form open one-dimensional channels packed in the hexagonal structure. Figure 1a schematically shows the framework structure of the AFI single crystal viewed along the [001] direction. The typical dimension of the AFI crystals used in our experiment is about 100 mm in diameter and about 300 mm in length. The A...

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