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The structural damping ratio, structural quality, yield strength, and elastic modulus of section steel, compressive strength, elastic modulus of concrete, yield strength, and elastic modulus of steel bars play important roles in the stability of the steel-reinforced concrete (SRC) frame structure, which are usually uncertain. However, their importance influence on the different seismic demands of SRC is rarely investigated simultaneously. In order to investigate the effects of the above parameters on four seismic demands (i.e., the top displacement, the maximum floor acceleration, the base shear force, and the maximum interstory displacement angle) of SRC frame structures, the orthogonal polynomial estimation method is first applied to the importance analysis of structural seismic demand based on the moment-independent method. Two engineering examples are performed to verify the accuracy and efficiency of the proposed method. The results have the characteristics of fast convergence and are in good agreement with those obtained by the moment-independent method based on kernel density estimation. The variance importance index based on Monte Carlo (MC) method is also calculated for comparison. The influence of each random variable on the four structural seismic demands is basically the same. Therefore, the accuracy and efficiency of the proposed method are proved sufficiently.

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