Two new phenolic acids, ethyl pro-lithospermate (1), n-butyl pro-lithospermate (2) were isolated from Salvia yunnanensis C.H.Wright, along with nineteen known compounds (3-21). The structures of the isolated compounds were elucidated on the basis of extensive spectrometry and by comparing their physical and spectroscopic data to the literature. Among them, compounds 11, 12 and 14-16 were firstly isolated from S. yunnanensis C.H.Wright. Some of the isolated compounds were evaluated for their neuroprotection. Compounds 10-12 showed significant neuroprotective effects in PC12 cells and compounds 1, 4-7 displayed moderate neuroprotective effects.
Five oleanane-type triterpene glycosides
including three new ones,
proceraosides E–G (1–3), were
isolated from a MeOH-soluble extract of Albizia procera bark. The structures of 1–3 were
determined by use of NMR spectra, HRESIMS, and chemical methods. Compounds 1–5 exhibited inhibitory activities against
the proliferation of the A549, SKBR3, AZ521, and HL60 human cancer
cell lines (IC50 0.28–1.8 μM). Additionally,
the apoptosis-inducing activity of compound 2 was evaluated
by Hoechst 33342 staining and flow cytometry, while the effects of 2 on the activation of caspases-9, -8, and -3 in HL60 cells
were revealed by Western blot analysis.
Countercyclical fiscal regulation can mitigate economic risk, but this is bound to increase the scale of local government debt during an economic downturn, and then spread risk to the banking sector, forming potential financial instability factors. We extracted the three most important variables in this process: economic fluctuation, local debt risk and bank risk-taking to build an econometric model and found that: (1) both economic fluctuations and local government bond risks have a significant impact on bank risk-taking, which is negatively correlated with local economic growth, while the increase of local government bond risks tends to increase bank risk-taking in the long run; (2) the impact of local government debt risk significantly increases the loans of city commercial banks flowing into the construction industry. Therefore, the impact of local government bond risk on city commercial banks is concentrated in the impact on their construction loans. This study has an important reference value for timely and moderate countercyclical regulation, preventing local debt risk from spreading to banks, constructing a sustainable local government−bank ecology, and promoting sustainable economic development.
The solubility data of sodium theophylline salt in the water and aqueous sodium hydroxide systems with molarities of 0.00, 0.01, 0.10, 0.20, 0.49, and 0.96 mol kg−1 at temperatures ranging from 283.15 to 368.15 K are determined via the equilibrium method. The experimental results show that the solubility of sodium theophylline increases on increasing the temperature at the same concentration of NaOH solution and decreases with an increase in the NaOH concentration at the same temperature. These results correlate well with the polynomial empirical equation, the modified Apelblat equation, and the λh equation. At the same time, it is found that the modified Apelblat equation gives better correlation results than the polynomial empirical and the λh equations. The results show that the three models correlate well with the solubility data of sodium theophylline. The modified Van’t Hoff equation is used to estimate the thermodynamic properties including the dissolution enthalpy, the dissolution entropy, and the Gibbs free energy change of sodium theophylline when dissolved in aqueous NaOH solution at different concentrations. The solubility data and correlation results obtained from the experiments can provide basic data for the cooling crystallization, separation, and purification of sodium theophylline and are expected to be of great significance for the research and development of sodium theophylline and for caffeine production.
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