Background: TNFR1 signaling has been intensively studied, but it remains unclear how TNFR2 transduces TNF-␣ signal under inflammatory conditions. Results: TNFR2 associates with IL-17RD, resulting in receptor aggregation and TRAF2 recruitment, leading to promotion of NF-B signaling in renal tubular epithelial cells. Conclusion: TNFR2 cooperates with IL-17RD to activate NF-B. Significance: The TNFR2⅐IL-17RD heteromer might be implicated in nephritis.

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An accelerator-driven subcritical system (ADS) program was launched in China in 2011, which aims to design and build an ADS demonstration facility with the capability of more than 1000 MW thermal power in multiple phases lasting about 20 years. The driver linac is defined to be 1.5 GeV in energy, 10 mA in current and in cw operation mode. To meet the extremely high reliability and availability, the linac is designed with much installed margin and fault tolerance, including hot-spare injectors and local compensation method for key element failures. The accelerator complex consists of two parallel 10-MeV injectors, a joint mediumenergy beam transport line, a main linac, and a high-energy beam transport line. The superconducting acceleration structures are employed except for the radio frequency quadrupole accelerators (RFQs) which are at room temperature. The general design considerations and the beam dynamics design of the driver linac complex are presented here.

No abstract