Brucea javanica oil (BJO) is widely used in traditional Chinese medicine to treat various types of cancer and inflammatory diseases. There is significant interest in understanding the medicinal activities of BJO and its molecular components, especially quassinoids, and in exploring how they can be incorporated into nanomedicine delivery strategies for improved application prospects. Herein, we cover the latest progress in developing different classes of drug delivery vehicles, including nanoemulsions, liposomes, nanostructured lipid carriers, and spongosomes, to encapsulate BJO and purified quassinoids. An introduction to the composition and medicinal activities of BJO and its molecular components, including quassinoids and fatty acids, is first provided. Application examples involving each type of drug delivery vehicle are then critically presented. Future opportunities for nanomedicine delivery strategies in the field are also discussed and considered within the context of translational medicine needs and drug development processes.
In this manuscript, we provided a new synthetic method to conveniently synthesize the mesoporous carbon platelets of high surface area (>1,000 m 2 /g), large pore size (≈8.0 nm), and short channel length (<100 nm) for the application in high-power supercapacitor. A co-assembly approach to prepare the phenol formaldehyde-Pluronic F127-calcium phosphate composite was proposed. In such composites, the PF-F127 organic parts occluded within the Ca 3 (PO 4) 2 crystals can be converted to mesoporous carbon platelets and the calcium phosphate is easily removed in an acidic aqueous solution rather than using a highly corrosive HF solution for silica removal. In practice, the platelets of relatively large mesopores, short pore channels, high specific surface area, and good electronic conductivity to meet the high power demands. It shows that the mesoporous carbon can have a rectangle-like shape i-E curve measured at a very high scan rate of 4,000 mV/s in 4.0 M H 2 SO 4. The novel mesoporous carbon platelets electrode exhibits only 29% loss when the scan rate is varied from 100 to 4,000 mV/s. The above perfect capacitive performances confirm the promising applicability of this novel mesoporous carbon for supercapacitors of ultrahigh power.
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