Combined resistance exercise protocols appear effective in preserving femoral neck and lumbar spine BMD in postmenopausal women, whereas resistance-alone protocols only produced a nonsignificant positive effect.

No abstract

To identify genetic markers for laryngeal squamous cell carcinoma (LSCC), we conducted a genome-wide association study (GWAS) on 993 individuals with LSCC (cases) and 1,995 cancer-free controls from Chinese populations. The most promising variants (association P < 1 × 10(-5)) were then replicated in 3 independent sets including 2,398 cases and 2,804 controls, among which we identified 3 new susceptibility loci at 11q12 (rs174549), 6p21 (rs2857595) and 12q24 (rs10492336). The minor alleles of each of these loci showed protective effects, with odds ratios (95% confidence intervals) of 0.73 (0.68-0.78; P = 1.00 × 10(-20)), 0.78 (0.72-0.84; P = 2.43 × 10(-15)) and 0.71 (0.65-0.77; P = 4.48 × 10(-14)), respectively. None of these variants showed an interaction with smoking or drinking. This is the first GWAS to our knowledge solely on LSCC, and the findings might advance understanding of the etiology of LSCC.

end point that the median PFS was significantly prolonged from 11.1 months to 20.7 months (HR = 0.53, P = 0.029). The incidence of treatment related adverse event (TRAE) was 100% and 89.7% in anlotinib and placebo groups. 20 of 62 patients in anlotinib group underwent dose reduction. The most common TRAE of all grades in the both groups included palmar-plantar erythrodysesthesia syndrome (62.9% vs. 10.3%) and proteinuria (61.3% vs. 10.3%). These results indicated the potential application of anlotinib in patients with MTC and support its approval as first TKI for the treatment of this disease in China.Research.

Hematoma often occurs within 12 hours after thyroid surgery. Hypertension, previous thyroid surgery, male sex, and benign pathology may increase the risk of hematoma.