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BackgroundThis study aimed to comprehensively explore the occurrence and risk factors for adverse events (AEs) and adverse drug reactions (ADRs) (especially for thrombocytopenia and bleeding) in Chinese patients with high bleeding risk (older adults, or complicated with diabetes mellitus or renal function impairment) undergoing percutaneous coronary intervention (PCI) with bivalirudin as an anticoagulant.MethodsA total of 1,226 patients with high bleeding risk who received PCI with bivalirudin as an anticoagulant from 27 Chinese medical centers were enrolled in this prospective, multi-center, intensive monitoring study. AEs, ADRs, thrombocytopenia, and bleeding were collected from admission to 72 h post-bivalirudin administration; subsequently, patients were followed up on the 30th day with the safety data collected as well.ResultsAdverse events were observed in 198 (16.2) patients, among which severe AEs occurred in 16 (1.3%) patients. Meanwhile, bivalirudin-related ADRs were reported in 66 (5.4%) patients, among which 5 (0.4%) patients experienced bivalirudin-related severe ADRs. Besides, thrombocytopenia and bleeding occurred in 45 (3.7%) and 19 (1.5%) patients, respectively. The subsequent multivariate logistic analysis revealed that age >75 years [p = 0.017, odds ratio (OR) = 1.856] and spontaneous coronary artery dissection (SCAD) (p = 0.030, OR = 2.022) were independently related to higher ADR risk; SCAD (p = 0.017, OR = 2.426) was independently correlated with higher thrombocytopenia risk, while radial artery access (p = 0.015, OR = 0.352) was independently correlated with lower thrombocytopenia risk; and the administration of bivalirudin preoperatively or intraoperatively (p = 0.013, OR = 5.097) was independently associated with higher bleeding risk.ConclusionBivalirudin presents a favorable safety profile regarding ADRs, thrombocytopenia, and bleeding in Chinese patients with high bleeding risk undergoing PCI.

By the total energy pseudo-potential approach of plane wave, we study the electronic and optical properties of the anatase TiO 2 systems with Sc-doped, oxygen vacancies included, and Sc and oxygen vacancies co-existing, respectively. The obtained results show that the contribution by the doped Sc lies mainly in the valence band, and the light absorption in the visible region is obvious. A Mott phase transformation takes place in the presence of oxygen vacancies, and the light absorption in the visible region is also obvious. In particular, the absorption in the visible region of the co-doped system is enhanced coherently due to the influences both from doped Sc and oxygen vacancies.

Key messageOsPEX1 is a negatively regulator of root growth in rice. The antagonistic action of OsPEX1 transcription and gibberellin biosynthesis mediates lignin deposition in root cell.

IntroductionThe Qibei slope is located within the Bohai Bay Basin, southwest of the Qikou sag between the Gangxi fault and the South Dagang fault (Figure1). West of the Qibei slope lies the Kongdian bulge, which is an eastward dipping slope structure with long-term development. Subject to different basement subsidence as well as the differential movements of the two major boundary faults, the Qibei slope can be divided into three flexural slope regions; from west to east, they include the: high slope, middle slope and low slope.The sandstones of the Es 2 and Es 3 Member of the Paleogene were supplied by the trough fault and distributed along the eastward dipping slope. The target layer is at the favorable burial depth and the reservoir property is good, correlating well with the slope break structure and the oil sources. It is a favorable zone for lithologic oil/gas accumulation. Identification and description of the lithologic trapBased on the drilled well, it has been verified that the Es 2 Member, which is one of the major target layer in the study area, is composed of thin interbeds of sandstones and mudstones. Deposition of the Es 2 was subject to the factors such as sedimentary source and palaeogeomorphology, such that the sand bodies exhibit strong variation in the vertical and horizontal directions, and the strata have complex geologic relations with the surrounding rocks. Consequently, uncertainties about the boundaries of the Es 2 Member exist. Therefore, the identification of the slope break and the division of the sedimentary facies were carried out using a sequence stratigraphic approach at the outset of the investigation. Subsequently, many geophysical methods such as seismic facies analysis, multi-parameter inversion and 3D visualization were applied within the range of the favorable sedimentary facies to predict the spatial distribution of the sand bodies, in order to effectively improve the prediction accuracy of the reservoir.