Natural products are important sources of therapeutic drugs. However, it is a challenge to simplify the structure of natural products without decreasing the biological activity. Here we provide the first example of the successful simplification of an antifungal natural product. Starting from sampangine, two novel simplified scaffolds with excellent antifungal activity were discovered.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.