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The authors apologize for any inconvenience caused. ). The phosphorylation of Y1131, Y1135 and Y1136 stabilizes the activation loop far away from the active site (orange), which is now occupied by the ATP analogue (green) and the peptide substrate (magenta). When these three Tyr residues are dephosphorylated (PDB code 1IRK; Hubbard et al, 1994), the activation loop occupies the same location as the peptide substrate, inhibiting its kinase activity.

No abstract