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Diabetes is a widespread metabolic syndrome, an important complication during pregnancy. Most cases are type 2 diabetes, which has attracted the attention of the World Health Organization. The typical feature of T2DM is insulin resistance (IR). Its mechanism remains unclear, but it mainly manifests through parameters like insulin sensitivity, blood glucose level, and liver stability. Oxidative stress and insulin transduction play an important role in IR. This study simulates the disease situation, establishes a high-fat and high-fructose-induced model induced by tert-butyl hydroperoxide (tBHP), and adopts nano-sized oleanolic acid combined with lipid-lowering ketones to explore improvement in the IR mechanism. We found combining nano-sized oleanolic acid and lipid-lowering ketones can slow down the weight gain process in rats, reduce fasting blood glucose levels, increase the insulin sensitivity index, reduce the serum MDA, NO, and triglyceride content, and increase SOD, CAT activity. In summary, our results show that the combined use of nano-sized oleanolic acid and lipid-lowering ketone in pregnant rats with double height can reduce glucose metabolism, delay lipid production, and reduce oxidative stress, which is useful for further treatment and interpretation of T2DM The mechanism provides a theoretical basis.

This study investigated the expression of IL-10 and Ki-67 in human cervical cancer and cervical intraepithelial neoplasia (CIN) and the correlation with human papillomavirus infection. A total of 110 patients with cervical lesions undergoing surgical treatment in Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine from 2016 to 2017 were selected. Those patients included 36 cases of cervical cancer and 74 cases of CIN. At the same time, 30 cases of chronic cervicitis were selected as the control group. RT-qPCR was used to detect the expression of IL-10 and Ki-67 in cervical tissue. PCR was used to detect HPV infection in cervical tissue. The expression levels of IL-10 and Ki-67 in the cervical cancer and CIN groups were higher than those in the control group. Moreover, the expression levels of IL-10 and Ki-67 in the cervical cancer and CIN II–III groups were higher than those in the CIN I group (P<0.05). In addition, the expression levels of IL-10 and Ki-67 in the cervical cancer group were significantly higher than those in the CIN II–III group. Furthermore, the expression levels of IL-10 and Ki-67 were positively correlated with HPV infection (r=0.783 or 0.712, P<0.05). Finally, the expression levels of IL-10 and Ki-67, and HPV infection in the cervical lesions studied were significantly different. Therefore, combined detection of IL-10, Ki-67 and HPV infection can improve the diagnosis of CIN and early cervical cancer.

The transition of motherhood is a challenge for women, which results in not only a physical burden but also mental disorders. [1][2][3][4] Postpartum depression (PPD) and postpartum anxiety (PPA) are common psychological problems that occur in up to approximately 20% of women, which result in detrimental effects on postpartum women 5,6 ; the common symptoms include insomnia, mood swings, loss of appetite, irritability, and even thoughts of self-harm and suicide. 7,8 In addition, PPD and PPA also have an adverse effect on the neurodevelopment of children, subsequently resulting in physical and psychological problems among children of women with PPD and

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