Abstract. With the economic globalization and social informatization, it has received more and more widespread attention to cultivate applied talents based on the cooperation of industry, university and research. In order to better cultivate applied talents and realize the people's all-round development, this paper explores the characteristics of the times, the historical inevitability and the selection of realistic paths of cultivating applied talents based on the three-in-one platform of industry-university-research. This paper holds that cultivating applied talents based on the three-in-one platform has the characteristics of the times of applicability, complexity and practicality. It has the historical inevitability in its development, which reflects the historical achievements of the continuous progress of science & technology, the objective requirements of the sustainable development of economy & society and the inherent requirements of the cultivation of modern talents and the development of higher education. It is the selection of realistic paths to cultivate applied talents based on the three-in-one platform for realizing the intersection of literal arts & sciences, the integration of knowledge & practice and the coordination of one specialty & multi-capability.

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