In the reported study, experimental liquid–liquid equilibrium (LLE) data for extracting isopropanol from cyclohexane utilizing 1,4-butanediol, 1,2-propanediol, dimethyl sulfoxide, and N,N-dimethylformamide as solvents were obtained at 303.2 K and atmospheric pressure. The separation factors derived from experimentally measured LLE data were computed to determine the extracting capability of the different solvents, and Othmer–Tobias, Hand, and Bachman equations were used to estimate the reliability and consistency of the LLE data. In addition, the nonrandom two-liquid (NRTL) thermodynamic model in Aspen Plus software was used to regress the LLE data, providing optimized binary interaction parameters. The regression results agreed well with the experimentally determined LLE values, indicating that the NRTL method was suitable to correlate the LLE data for the four ternary systems.