An environmentally benign method has been developed for the synthesis of novel chiral thiourea derivatives in high yields in ionic liquid [Bmim]PF 6 . The ionic solvent can be recovered and reused without any loss of its activity. The target compounds were characterized by elemental analysis, IR, 1 H NMR and 13 C NMR spectral data. According to the preliminary bioassay, some of the chiral thiourea analogues exhibited moderate in vivo antiviral activities against TMV at a concentration of 500 mg/L. Title chiral compound 3i was found to possess good in vivo protection, inactivation and curative activities of 57.0%, 96.4% and 55.0%, respectively against TMV with an inhibitory concentration at 500 mg/L. The title chiral compound 3i revealed better inactivation effect on TMV (EC 50 ＝50.8 µg/mL) than Ningnanmycin (EC 50 ＝60.2 µg/mL).

Thiourea derivatives Q 0650Synthesis and Antiviral Activities of Chiral Thiourea Derivatives. -Chiral thioureas (IIIb) and (V) show moderate antiviral activities against tobacco mosaic virus (TMV). Derivative (IIIa) possesses antiviral activity against TMV comparable with that of the reference antiviral agent Ningnanmycin. -(YAN, Z.; CAI, X.; YANG, X.; SONG*, B.; CHEN, Z.; BHADURY, S. P.; HU, D.; JIN, L.; XUE, W.; LU, P.; Chin. J. Chem. 27 (2009) 3, 593-601; Res. Dev. Cent. Fine Chem., Guizhou Univ., Beijing 550025, Peop. Rep. China; Eng.) -R. Staver 31-085