Two-thirds of the lipid A in wild-type-component regulatory system, and also occurred in E. coli msbB or htrB mutants. The lipid A variants that accumulate in NH 4 VO 3 -treated E. coli K12 are the same as many of those normally found in untreated Salmonella typhimurium and Salmonella minnesota, demonstrating that E. coli K12 has latent enzyme systems for synthesizing these important derivatives.

The Escherichia coli msbA gene, first identified as a multicopy suppressor of htrB mutations, has been proposed to transport nascent core-lipid A molecules across the inner membrane (Polissi, A., and Georgopoulos, C.

Overexpression of the