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Periungual wart is a kind of verruca vulgaris that occurs alongside or underlying the nails, which is challenging to treat and prone to recurrence, seriously affecting the quality of patients’ life. We report a 6-year-old boy with periungual warts who had experienced various treatments with no improvement and even worsening. Therefore, we tried to treat the patient with local hyperthermia which uses a patented device that has an infrared emission source. The heat generated by infrared rays acts on the local skin surface. The mechanism of this therapy may be to establish a specific immune response against human papillomavirus-infected tissues, thereby facilitating the clearance of human papillomavirus at irradiated and non-irradiated sites. Local hyperthermia has the advantages of non-contact, safety, noninvasive, less pain, and so on. After 5 treatments, the irradiated periungual warts completely cleared after 2 weeks. The unirradiated sites were almost cured after 7 weeks. This case suggests that local thermotherapy has shown great advantages in the treatment of these refractory periungual warts and offers a new and effective therapy in patients with periungual warts.

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Background Herpetic folliculitis (HF) is a rare manifestation of herpes virus infection of the skin, which has different presentations causing frequent misdiagnosis. Previous literature has reported follicular infections caused by herpes simplex virus (HSV) in the beard area, called herpetic sycosis, but only a few cases presented facial extensive folliculitis. Purpose This case series aimed to describe the clinical features of facial generalized herpetic folliculitis. Methods We retrospectively collected a case series of 20 patients with facial diffused herpetic folliculitis diagnosed clinically or experimentally from outpatients between 2012 and 2022. The reported cases similar to HF of literature were concluded. Results There were 19 females and 1 male in this study. Disease duration varied from 1 to 10 days, and lesion manifestations were predominantly papules and maculopapules. Most patients suffered spontaneous pain or pruritus and recovered with antiviral treatment. All cases achieved great improvements in lesions after antiviral and topical medication therapy. Conclusion This case series suggests that in patients with infectious folliculitis of the face when the lesions develop acutely and diffusely, dermatologists should take into account the possibility of herpetic folliculitis, especially in cases where antibacterial or antifungal therapy is resistant, and actively administer antiviral therapy after diagnosis.