Value of differential diagnosis of contrast-enhanced ultrasound in benign and malignant thyroid nodules with microcalcification was explored. A total of 184 patients with thyroid nodules with microcalcification, treated in People's Hospital of Shanxi Province from April 2015 to March 2017, were selected as research subjects. Contrast-enhanced ultrasound was used for imaging examination of the thyroid nodules. Three regions of interest were drawn at the positions with the strongest ultrasound imaging, for which the time-intensity curve (TIC), time to peak (Tp), peak intensity (Peak), area under curve (AUC) and mean transit time (MTT) were obtained separately. The features of contrast-enhanced ultrasound for malignant thyroid nodules were manifested as irregular focus edge, unclear boundary, low fiber reinforcement of the whole focus, uneven distribution of images and blood perfusion defect inside the focus, especially severe blood perfusion defect in the nodule center. The TIC showed a slow ascending and slow descending trend in general. The TIC features and the features of contrast-enhanced ultrasound for malignant thyroid nodules were prominently different from those for benign thyroid nodules. Compared with those in the surrounding normal tissues of thyroid gland, the Peak was remarkably shorter, and the AUC was notably smaller in the center and edge of malignant thyroid nodules (P<0.05); and the nodule center had obviously shorter Peak and smaller AUC than the nodule edge (P<0.05). Furthermore, in comparison with those of malignant thyroid nodules, the Peak was extended and AUC was enlarged markedly in the center and edge of benign thyroid nodules (P<0.05). In conclusion, the contrast-enhanced ultrasound can preferably compare the lesions of benign and malignant thyroid nodules with microcalcification, which possesses certain value in the differential diagnosis of benign and malignant thyroid nodules.

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