B fields in the ROI. c) Variation of the mean signal with FAs and fitting results of λ r and λ t . A spoiled gradient echo sequence (SPGR) was used in the MRI experiment. d) λ t and λ r mappings. λ t is the enhancement ratio of the ACWM on the real FA or transmitting field, and λ r is the enhancement ratio corresponding to the signal intensity. Scale bar: 100 mm.

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Notch signaling is a highly conserved signaling pathway, playing an important role in a variety of cell differentiation, development and regulation. Notch signaling includes Notch1-4; Notch1 gene encodes Notch1 signaling that can shorten cell cycle, enhance cell proliferation, inhibit cell differentiation, and promote apoptosis. Mutation and overexpression of the Notch1 gene may induce tumorigenesis, which plays an important role in the development of tumors across a variety of signaling pathways. Currently, using RNA interference technology (RNAi) synthesizing small interference RNA (siRNA) targeting Notch1 gene (siNotch1) has become a hot topic, and clinical application of gene silencing has also obtained a certain therapeutic effect. In this paper, the application of Notch1 gene silencing in tumor progress was reviewed. (Int J Biomed. 2016;6(3):163-166.).

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