A 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ)-catalysed electrochemical synthesis of 2-amino-1,3,4-thiadiazoles from isothiocyanates and hydrazones is presented. This protocol is mild, practical, metal-free and exogenous oxidant-free, and features a broad substrate scope. Extensive mechanistic...

A visible-light-induced regioselective tandem enamido β-C(sp 2 )À H alkylation/acrylamido alkylation/cyclizative alkenylation sequence of 3aza-1,5-dienes is presented. This protocol is regiospecific, features a broad substrate scope, and provides a direct access to 3,4-dialkylated 4pyrrolin-2-ones from readily available N-alkenylacrylamides. It is readily scalable to a gram scale, and could be induced by natural sunlight.

A chemical reductant or a sacrificial electron donor is required in any reduction reaction, generally resulting in undesired chemical wastes. Herein, we report a reductant-free reductive [3+2+1] annulation of β-keto...