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have shown that the expression of ITIH4 in cancer patients is related to tumorigenesis and cancer progression, suggesting that ITIH4 may be used as a serological marker for diagnosis cancer (6-8). Our cytological studies have also shown that 70 kDa ITIH4 protein fragments are expressed in gastric cancer cells. In addition, our study also found that elevated serum ITIH4 in patients with early gastric cancer was strongly associated with Helicobacter pylori (H. pylori) infection and serum IL-6 levels. So far, however,

Purpose: To elucidate the role of TGF-β2 and Fenofibrate in DR concomitant with HUA.Methods: In vitro, human retinal endothelial cells (HRECs) were incubated with high glucose(HG), HUA and HG mixed HUA respectively. The apoptosis rate was evaluated by TUNEL assay and Capase-3 activity. TGF-β2 and VEGF was detected by Western blot and real-time PCR. The therapeutic effect of Fenofibrate was revealed by detecting the level of peroxisome proliferator activated receptor a(PPARa) through Western blot and real-time PCR.Results: The level of cellular apoptosis, TGF-β and VEGF was conducted to increase most significantly in presence of HG mixed HUA stimulated HRECs. HG mixed HUA led to PPARa suppression which resulted in activated TGF-β2 expression, and this effect could be inhibited by Fenofibrate.Conclusion: TGF-β2 might be a pivotal mediator for the progression of DR with uric acid stress and Fenofibrate could be an important pathway to ameliorate diabetic complication.